• br Cellular transportation of nanoparticles and nanocomplexe

  2022-05-05

  

  Cellular transportation of nanoparticles and nanocomplexes Endocytosis and exocytosis are critically important phenomena in cellular metabolism, which involve the complex vesicular system. They deal with major cellular transportation activities including membrane homeostasis by transporting prote

• The fact that GSK recognition of

  2022-05-04

  

  The fact that GSK-3 recognition of its substrate involves pre-phosphorylation supports the rational for using synthetic phosphorylated peptides as substrate competitive inhibitors [57]. Phosphorylated peptides derived from the N-terminal pseudosubstrate sequence of GSK-3β were very weak inhibitors o

• Mouse FGF21 / Fibroblast Growth Factor 21 Protein (His Tag)

  2022-05-04

  

  Other Functions of HCA Receptors HCA receptors, in particular HCA1, are expressed in various primary tumor Mouse FGF21 / Fibroblast Growth Factor 21 Protein (His Tag) 77, 78, 79. This is of interest, as most solid tumors show increased glucose uptake and lactate formation even under normoxic co

• The discovery that the physiological functions

  2022-05-04

  

  The discovery that the physiological functions of LPI are associated with the activation of specific GPR55 membrane receptor [4] has launched a new era of research on this lysophospholipid. However, the activation of membrane receptors by lysophospholipids is extremely complex due to the multitude o

• br Introduction The amino acid glycine functions as a

  2022-05-04

  

  Introduction The amino POM 1 glycine functions as a neurotransmitter in the vertebrate central nervous system: as an inhibitory neurotransmitter and as a co-agonist of the NMDA-subtype of excitatory glutamatergic receptors (Eulenburg et al., 2005). Under a current hypothesis that schizophrenia re

• P gps expressed in cells and tissues

  2022-05-04

  

  P-gps, expressed in 7ACC1 synthesis and tissues of human and animals, play an active role in cellular protection against multiple toxicants by transporting them out of a cell. Thus, improving transport activity of P-gp may contribute to removing Cd from living oysters. Cd accumulation in the culture

• The precise mechanisms of action of

  2022-05-04

  

  The precise mechanisms of action of 4-PBA are as yet ambiguous. Its capacity as a chemical chaperone has been thoroughly documented for the ABC transporter family in particular (Prulière-Escabasse et al., 2007; Iram and Cole, 2014; Gordo-Gilart et al., 2016; Pomozi et al., 2017). 4-PBA has been clas

• Interestingly mGlu and mGlu receptors differ notably by thei

  2022-05-04

  

  Interestingly, mGlu2 and mGlu3 receptors differ notably by their cellular distribution. Whereas mGlu2 receptors are mostly neuronal, mGlu3 receptors are expressed both in glia and in neurons. In neurons, mGlu3 receptors are present at the post-synapse and in presynaptic elements (Tamaru et al., 2001

• This data is in accordance with our recent results on

  2022-05-04

  

  This data is in accordance with our recent results on the influence of cholesterol-depleting agent methyl-β-cyclodextrin on platelets (Borisova et al., 2011a). Dissipation of the proton electrochemical gradient of secretory granules by methyl-β-cyclodextrin did not evoke the release of endogenous g

• In conclusion enhanced glucagon action of the

  2022-05-04

  

  In conclusion, enhanced glucagon action of the beta cell results in improved beta cell function after glucose stimulation, but simultaneously dissociated responses to both glucose-dependent and non-glucose secretagogues evolve. This shows that the glucagon receptor is complexly involved in beta cell

• The ghrelin receptor is expressed in

  2022-05-04

  

  The ghrelin receptor is expressed in a number of human malignancies including prostatic carcinoma cell lines [18,19] and tissues [20], breast carcinoma tumours and cell lines [21], testicular tumours [22], and malignant ovarian cysts and tumours [23]. In addition, it has an elevated level of express

• The mechanism by which Piezo

  2022-05-04

  

  The mechanism by which Piezo1 acts in the regulation of RBC volume is not firmly established. Its curved structure implies that it is activated by an increase in membrane tension (11), a mechanism indicated by electrophysiological measurements (16). However, the RBC membrane mechanics at its physiol

• cystamine Studies regarding secretase nowadays aim

  2022-05-04

  

  Studies regarding γ-secretase nowadays aim at elucidating how APP is recognized and recruited. It has been suggested based on coarse-grained molecular simulation that the recognition and recruitment of substrate can occur on an extended surface covering PS1's TM2/6/9 domains and PAL motif [15]. Tran

• It should be noted that the applied steered

  2022-05-04

  

  It should be noted that the applied steered unfolding of the i-motif and G-quadruplex satisfies the conditions of Jarzynski inequality for computations of the free energy change. [41] However, in order to reproduce the free energy with an adequate quality a number of nonequilibrium unfolding transit

• Clinical data showed TAK was rapidly absorbed

  2022-05-04

  

  Clinical data showed TAK-875 was rapidly absorbed with a half-life of 28-30h and clearance primarily through glucouronidation in the liver with minimal urinary clearance [30]. TAK-875 made the glycosylated hemoglobin (HbA1c) levels fall significantly from baseline after 24-week administration in onc

15973 records 468/1065 page Previous Next First page 上5页 466467468469470 下5页 Last page