• The study of TcMYH protein is a step

  2022-05-07

  

  The study of TcMYH protein is a step forward for the characterization of a GO system in T. cruzi. The complete system appears to be present and our findings demonstrate that is important to maintain DNA stability of the nuclear and mitochondrial genomes, particularly in the presence of oxidative str

• br Author s contributions br Conflict of interest br

  2022-05-07

  

  Author's contributions Conflict of interest Acknowledgements This work was supported in part by a grant from Department of Biotechnology (DBT), Government of India (Sanction Order No.: BT/563/NE/U-Excel/2016). MC, PDG and SKM acknowledge the Ministry of Human Resource and Development (MHRD)

• Increased expression of Glut is detected in a number of

  2022-05-07

  

  Increased expression of Glut1 is detected in a number of cancer types including lung [7], brain [8], bladder [9], cervical [10], colorectal [11], esophageal [12], hepatocellular [13], head and neck [14], gastric [15], ovarian [16], renal cell [17], pancreatic [18], thyroid [19] and breast [20]. Over

• The plasma levels of glucose and amino acids at day

  2022-05-07

  

  The plasma levels of glucose and amino acids at day 0 likely represent the function in utero since the blood was collected within 2h after birth. To elucidate the roles of intestinal transporters as determinants of plasma levels of glucose and amino acids, we analyzed the correlation between the exp

• Genetic disruption or pharmacologic inhibition of the

  2022-05-07

  

  Genetic disruption or pharmacologic inhibition of the hepatic glucagon pathway has invariably been shown to increase pancreatic α cell mass. This has been observed in glucagon receptor (GCGR) knockout (Gcgr−/−) mice (Gelling et al., 2003), glucagon knockout mice (Hayashi et al., 2009), prohormone co

• 2272 GLP and glucose dependent insulinotropic peptide GIP ar

  2022-05-07

  

  GLP-1 and glucose-dependent insulinotropic peptide (GIP) are gut hormones secreted from intestinal L 2272 and K cells, respectively. Together, these hormones account for the vast majority of the incretin effect, the enhanced postprandial insulin secretion observed in healthy adults (Dupre et al., 1

• br Biologically active non peptide galanin receptor ligands

  2022-05-07

  

  Biologically active non-peptide galanin receptor ligands The first successful attempt in overcoming these weaknesses was undertaken by Saar et al. (2002). Screening of galanin sequence established that Trp-2, Asn-5, Tyr-9 were pharmacophores, responsible for biochemical action of the peptide. Bas

• Tianeptine sodium br Pathological consequences of disruption

  2022-05-07

  

  Pathological consequences of disruption in the GABA/T current equilibrium This issue has been particularly investigated in the context of absence seizures. These seizures are non-convulsive epileptic attacks present in many generalized genetic epilepsies that are characterized by a sudden and rel

• Herein we describe the design and optimization of fused ring

  2022-05-07

  

  Herein, we describe the design and optimization of fused-ring phenyl propanoic acids as novel GPR40 agonists, leading to the discovery of compound 40a which exhibits excellent pharmacokinetic properties, improved hepatobiliary transporter inhibition, and significant glucose-lowering efficacy during

• To further investigate if GPR was the functional

  2022-05-07

  

  To further investigate if GPR40 was the functional target of these phenylpropiolic GSK2578215A receptor analogs, GW-1100, a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells with an IC50 value equal to 1 μM, was used to inhibit agonist-induced intracellular calcium flux [15]. H

• FSLLRY-NH2 Considering the fact that NADPH oxidase is

  2022-05-07

  

  Considering the fact that NADPH oxidase is the main source for paraquat and maneb-induced oxidative stress, we hypothesized that NADPH oxidase activation might contribute to dopaminergic neurodegeneration induced by paraquat and maneb through ferroptosis. To test our hypothesis, we investigated the

• In enzyme assays it is convenient to quantify

  2022-05-07

  

  In enzyme assays, it is convenient to quantify the product formed in the enzyme reaction, where a decrease in the concentration of product indicates enzyme inhibition [35], [36], [37], [38]. In the present study, substrates were carefully chosen so that they are specific to each enzyme. Known natura

• About of human primary melanomas and of melanoma metastases

  2022-05-06

  

  About 67% of human primary melanomas and 56% of melanoma metastases display cytoplasmic or nuclear β-catenin accumulation (Xue et al., 2016). Of note, active β-catenin stimulates emergence of metastasizing melanoma in mice harboring BrafV600E or NrasQ61K hyperplasia (Damsky et al., 2011, Delmas et a

• Betahistine N methyl pyridyl ethylamine is a well known

  2022-05-06

  

  Betahistine (N-methyl-2-(2-pyridyl)ethylamine) is a well-known dual H1 QX 314 bromide agonist/H3 receptor antagonist with structural resemblance to histamine. Though it has been approved long before the discovery of H3R to treat disorders of vestibular function as Menières-Disease, the evidence for

• Adenine sulfate australia br Conclusion br Introduction Gast

  2022-05-06

  

  Conclusion Introduction Gastric adenocarcinoma (GA) is the fifth most commonly diagnosed malignancy and the third most common cause of death due to cancer worldwide. It is a highly aggressive cancer and 5-year survival rate (5YSR) is usually Adenine sulfate australia synthesis might be one of

15973 records 466/1065 page Previous Next First page 上5页 466467468469470 下5页 Last page