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Imatinib was first approved for the treatment of
2025-03-03
Imatinib was first approved for the treatment of Philadelphia chromosome positive chronic myelogenous leukemia in 2001 [25]. This first approved small molecule antagonist is quite unusual in that it provides a durable response that lasts for more than a decade in the majority of patients. Imatinib h
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In this study using pure
2025-03-03
In this study, using pure enzyme preparations of human placental recombinant AR (hAR) and of AR isolated from bovine lens (bAR), which behave as Michaelis Cyprodime hydrochloride with glyceraldehyde as substrate, is shown that an apparent negative cooperativity action for glucose still occurs. We p
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Interaction between AhR and ligands
2025-03-03
Interaction between AhR and ligands leads to AhR transformation (Fig. 1), characterized by a rapid receptor nuclear translocation and the formation of AhR/Arnt complex and the release of the chaperone proteins. Following AhR transformation, the AhR/Arnt complex binds to its cognate DNA consensus seq
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Control of retinal vascularization during development and
2025-03-03
Control of retinal vascularization during development and OIR likely involves close interactions among endothelial cells, neurons and glial FIPI (microglial and astrocytes) (see Fig. 2). In particular, the interaction between endothelial tip cells and astrocytes plays a critical role in developmenta
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PAN induced nephrosis was accompanied by loss of
2025-03-03
PAN-induced nephrosis was accompanied by loss of body weight, decrease of food intake, increase in urine volume and increases in triglycerides and cholesterol levels, which have been reported previously (Natori et al., 1996). Except for urine volume, each one of these measures was improved by A-3069
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br AMPK structure and mechanism of action AMPK is a
2025-03-03
AMPK: structure and mechanism of action AMPK is a metabolic master switch that regulates downstream signals based on shifts in the surrounding energy reservoir [6]. It is expressed in a number of tissues, including the kidney, the liver, the skeletal muscle, the adipose tissue, and the hypothalam
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EZ Cap™ Cre mRNA Until now there are no report regarding the
2025-03-03
Until now, there are no report regarding the relationship of CD21 and MG. In the present study, we aimed to characterize the AchR specified EZ Cap™ Cre mRNA and investigated the role of CD21 in immunopathogenesis of MG. We utilized the Allophycocyanin (APC)-conjugated AchR to measure the frequencie
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During the year study period of men
2025-03-03
During the 4-year study period, 19.9% of men in the dutasteride group developed prostate cancer as compared to 25.1% in the placebo group, which represents an absolute risk 2-NBDG of 5.1% for men taking dutasteride (Pe weighed against the prospect of undesirable sexual side effects and decreased qu
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At present drugs that specifically inhibit
2025-03-03
At present, drugs that specifically inhibit YAP activity are not available. In fact, verteporfin, which was originally described as a specific inhibitor of YAP-TEAD interaction, has been recently shown to exert its activity through selective induction of proteotoxicity rather than through YAP inhibi
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br Introducing toll like receptors TLRs are
2025-03-01
Introducing toll like receptors TLRs are the most important receptors which are expressed on the cytoplasmic and internal vesicles membrane. They have a similar structure including a leucine-rich repeats (LRRs) domain which is out of cas chemical membrane, a hydrophobic transmembrane and a toll/
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Gene regulation of MMPs is
2025-03-01
Gene regulation of MMPs is influenced by the transcription factor activating factor-1 (AP-1). AP-1 complexes are heterodimers of proteins of the two proto-oncogene families (jun and fos) and have urat1 inhibitor in the promoter region of MMPs, as well as in genes mediating inflammatory responses. Th
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Finally terbinafine is generally associated
2025-03-01
Finally, terbinafine is generally associated with a low index of toxicity and few adverse effects. In humans, only mild GI toxicity and hepatobiliary dysfunction are reported. In red-tailed hawks, oral administration of a high dose of terbinafine (120 mg/kg BW) was furthermore demonstrated to induce
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br AR signals and chemosensitivity in
2025-03-01
AR signals and chemosensitivity in urothelial cancer A significant amount of patients with urothelial cancer fail to respond to cisplatin-based systemic chemotherapy, although it remains the mainstay of successful management of advanced disease. However, underlying mechanisms for chemoresistance
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Women are usually at risk of sleep deprivation or
2025-03-01
Women are usually at risk of sleep deprivation or restriction during pregnancy, especially in the third trimester of gestation, due to the pregnancy-associated anatomic, physiological and hormonal changes (Pien and Schwab, 2004). However, several major n-acetyl-l-cysteine developmental events, such
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Calcium entry through postsynaptic NMDARs activates intracel
2025-03-01
Calcium entry through postsynaptic NMDARs activates intracellular signaling cascades including Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and calcineurin. The spatiotemporal abundance of this Ca2+/CaM complex determines the direction of synaptic plasticity, resulting in LTP (Malinow