• The physiological role of lactate induced antilipolytic effe

  2021-11-02

  

  The physiological role of lactate-induced antilipolytic effects is less clear. It has been speculated that GPR81 mediates the inhibition of lipolysis during intensive exercise, a condition which results in high systemic lactate plasma concentrations 9, 10. Owing to oxygen shortage resulting from int

• Both GPR A and GPR are

  2021-11-02

  

  Both GPR109A and GPR81 are located on chromosome 12q24 [3] and mediate anti-lipolytic effects through coupling to Gi-type G proteins [17]. It is important to note that with the recent deorphanization of these receptors, there has been a recommendation to the International Union of Basic and Clinical

• BCCA occlusion followed by reperfusion injury significantly

  2021-11-02

  

  BCCA occlusion, followed by reperfusion injury, significantly increased the brain AT1 and AT2 receptor expression in mice. Reports have demonstrated elevation of AT1 receptor expression in the cerebral Nicotine during ischemia [34,35]. The gene expression of brain AT2 receptor is increased in both

• As our earlier study investigated

  2021-11-02

  

  As our earlier study investigated glut mRNA levels in response to a protein load contained in a meal and the studies that used glucose and insulin injections did not examine GLUT expression, this study sought to investigate the effects of hyperglycaemia and insulin on mRNA levels in the spiny dogfis

• GK allosteric activators validate the importance of GK from

  2021-11-02

  

  GK allosteric activators validate the importance of GK from a therapeutic perspective, but the nature of allosteric activation of GK remains unclear. The GK allosteric activator site, the pocket where GKAs bind, is ~20 Å remote from the active site (Fig. 1A). The allosteric site is the locus of many

• In order to consolidate our genetic funding

  2021-11-02

  

  In order to consolidate our genetic funding, we performed several in silico analysis regarding the p.R85W mutation. The high conservation of R85 residue in all species suggests that it has an important role in glucokinase function. Pathogenic effect of the p.R85W is supported by in silico prediction

• br Acknowledgements Supported by the

  2021-11-02

  

  Acknowledgements Supported by the grant from National Natural Science Funds of China (81371262). I would like to express my heartfelt gratitude to Professor Yonghua Zhu, who help language editing. Introduction Glucocorticoids are steroid hormones secreted from the adrenal glands in response t

• Rare mutations can impair the molecular function of

  2021-11-02

  

  Rare mutations can impair the molecular function of GR and alter tissue sensitivity to GCs in humans, resulting in primary generalized GC resistance (PGGR) and hypersensitivity (PGGH) [14]. Familial and sporadic PGGR, or Chrousos Syndrome, is characterized by general and partial insensitivity of tis

• There is increasing evidence that Cxs in

  2021-11-02

  

  There is increasing evidence that Cxs in astrocytes may play a role in several models of brain pathologies. Interestingly their roles are at the moment more considered through their hemichannel function (Bennett et al., 2012; Bosch and Kielian, 2014; Davidson et al., 2013; Orellana et al., 2016; Kim

• There are multiple docking platforms suitable for use

  2021-11-02

  

  There are multiple docking platforms suitable for use with nucleic dna synthesis inhibitors receptors. These include: DOCK v4-6 (UCSF) [[68], [69], [70]], AutoDock (Scripps) [71], AutoDock Vina (Scripps) [72], GOLD (Cambridge Crystallographic Data Centre) [73], Surflex-DOCK (BioPharmics) [74], Glid

• The exact mechanism by which N BPs inhibit

  2021-11-02

  

  The exact mechanism by which N-BPs inhibit FPPS remains unclear. Computer modeling [10] suggests that N-BPs mimic the structure of the enzyme’s natural isoprenoid pyrophosphate substrates, geranyl pyrophosphate (GPP)/dimethylallyl pyrophosphate (DMAPP) or act as carbocation transition state analogs

• It is well known that

  2021-11-02

  

  It is well known that TLR4-induced inflammation is associated with behavioural alterations including fever, hypolocomotion, altered appetite, anxiety and anhedonia (Dantzer, 2006, Dantzer et al., 2008). The current data demonstrate that while PF3845 potently attenuates TLR4-induced cytokines in the

• Among the various epigenetic mechanisms involved in EwS path

  2021-11-02

  

  Among the various epigenetic mechanisms involved in EwS pathogenesis, we focused on the PRC enzyme EZH2, since it is a direct target of EWSR1-FLI1 and a critical mediator of malignant cell growth.24, 30 Our observation that the inhibition of EZH2 in GD2neg EwS Ginsenoside Rd induces GD2 expression

• Gadodiamide br Materials and methods br Results and discussi

  2021-11-01

  

  Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa Gadodiamide to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in the total ce

• br Introduction Erythropoietin EPO is a glycoprotein hormone

  2021-11-01

  

  Introduction Erythropoietin (EPO) is a glycoprotein hormone and the principal stimulator of erythropoiesis (Jelkmann, 2011). EPO promotes the proliferation and differentiation of red blood cells, which is important for oxygen transport. Low EPO levels in blood cause anemia; however, excessive lev

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