• Introduction The assessment of hormonal receptor HR

  2019-05-22

  

  Introduction The assessment of hormonal receptor (HR) and human epidermal growth factor receptor-2 (HER2) status by immunohistochemistry (IHC) groups breast cancer into three major subtypes: 1) luminal-like subtype (HR positive/HER2 negative); 2) HER2 subtype (HER2 positive and HR negative/positive

• br Conclusion br Financial support This research was support

  2019-05-22

  

  Conclusion Financial support This research was supported by a grant from the ׳Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon׳ [GRS 308/A/08] and ‘Caja Burgos Foundation’ [Convocatoria 2007].The funding organization had no involvement in the study. Clinical trial registra

• Introduction Atrial fibrillation AF is the

  2019-05-22

  

  Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia managed in clinical practice and the most common arrhythmia requiring hospitalization [1,2]. Thromboembolism occurs with similar incidence, regardless of the form of AF [3,4]. AF management includes anticoagulation to preve

• br Bile acids as therapeutic agents br Conclusion

  2019-05-22

  

  Bile acids as therapeutic agents Conclusion Bile acids are important physiological agents for nutrient GSK256066 and integrators of glucose, lipid, and energy metabolism control. Bile acid synthesis is tightly regulated to maintain metabolic homeostasis and prevent accumulation of highly toxic

• Paralelamente Chucho Hegel increpa al Profesor Sin

  2019-05-21

  

  Paralelamente, Chucho Hegel increpa al Profesor: “Sin dejar de ser el mismo, te has convertido en el otro como el blanco que se pinta de negro en el teatro bufo”. Pone, así, sobre el tapete, el que quizá sea el mayor de los demonios contra los que lucha el Profesor, personaje, éste, que deja espacio

• br Pathophysiology and risk factors Patient

  2019-05-21

  

  Pathophysiology and risk factors Patient with CIED may get infected at time of initial pgi2 or during pocket revision for device change or upgrade [8,2]. Device erosions are by default infected but most commonly are a secondary manifestation of slow growing underlying infection [8]. Pocket infect

• The benign exostoses in TRPS have

  2019-05-21

  

  The benign exostoses in TRPS have a recognized malignant potential which have been shown to develop into chondrosarcomas [4,13]. Both our index case and his mother demonstrated de novo high grade osteosarcoma. To our knowledge, this occurrence has not been described anywhere within the literature.

• br There is growing recognition that children

  2019-05-21

  

  There is growing recognition that children bear a substantial burden of tuberculosis morbidity and mortality. However, in regions where the diagnosis is contingent on smear microscopy, the burden attributable to children, who usually have paucibacillary disease, is grossly underestimated. The down

• La Historia natural o moral de las Indias de Joseph

  2019-05-21

  

  5. La Historia natural o moral de las Indias de Joseph de Acosta (1540-1600), impresa en 1592, recoge con gran concisión y puntualidad hechos históricos al tiempo que explica los aspectos de la naturaleza que, desde su perspectiva, no han sido tratados en forma adecuada por las fuentes anteriores. E

• The coverage and quality of laboratory services

  2019-05-21

  

  The coverage and quality of laboratory services throughout Africa is inadequately documented. Quality provided by individual laboratories is questioned, and not all facilities are enrolled in external quality assurance schemes. For example, in 2013, an evaluation of accredited laboratories in sub-Sa

• It was imperative to make patients a first

  2019-05-21

  

  It was imperative to make patients a first priority who had a definitive diagnosis needing immediate, timely, and effective interventions, including primary coronary intervention (PCI), permanent FLAG tag Peptide implantation, and were most likely to be admitted to CCU postprocedurally (Table 1). I

• Hereditary syndromes with increased risk

  2019-05-20

  

  Hereditary syndromes with increased risk for gastric cancer include: 1) hereditary diffuse gastric cancer, 2) Lynch syndrome/hereditary non-polyposis colorectal cancer, 3) juvenile polyposis syndrome, 4) Peutz-Jeghers syndrome and 5) familial adenomatous polyposis. Hereditary diffuse gastric cancer

• The effects of zoledronic acid are most likely due to

  2019-05-20

  

  The effects of zoledronic Rapalink-1 are most likely due to impairment of the tumour-driven alterations to the bone microenvironment. This may render the bone marrow cavity unfavourable for metastatic growth, potentially redirecting tumour cells to other sites, including the periosteal surface. Whe

• Extensive vascularization of the skeletal tissue suggests th

  2019-05-20

  

  Extensive vascularization of the skeletal tissue suggests the importance of blood vessels in regulating its physiological functions. Endothelium, the innermost cellular layer of blood vessels forms a central component of the bone marrow vascular microenvironment [7]. Recent evidence support that a p

• A number of clinical studies have

  2019-05-20

  

  A number of clinical studies have confirmed the beneficial effect of ranolazine in either prevention or treatment of AF. The first strong evidence was provided by MERLIN-TIMI 36 trial [the Metabolic Efficiency With Ranolazine for Less Ischemia in Non–ST-Elevation Acute Coronary Syndrome–Thrombolysis

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